Virus retention filtration is a very effective method for mitigating the viral risk of cell culture media. This filter targets non-enveloped viruses, such as MVM and vesivirus, and large-enveloped viruses, such as MuLV. Virosart® Media is specifically designed to filter virus-defined cell culture media viruses.
The multiple contaminants of bioreactors recorded over the last few years are caused by small non-enveloped viruses such as MVM and vesiviruses derived from raw materials.
The new strategy involves removing the virus before the bioreactor, immediately after media preparation, to prevent potential contamination of the bioreactor. Virus filtration is a proven and well-established technology on the market to remove all types of viruses (range > 20 nm).
Virosart® Media shows high retention in all tested organisms. Reliable virus retention filter performance helps mitigate risk and increases speed from the process itself to commercial scale.