Sartobind membranes for all process applications
Sartobind® membrane adsorbers have been reliably used in commercial processing for over two decades. The high flow rates of these adsorption membranes make them 150 times faster than traditional columns. Capsules can be handled like filters, and cassettes can be set up in less than 10 minutes.
From 96-well plates to 5 L capsules and modular cassettes, Sartobind® offers linear scalability across all process scales. High flow rates (5 – 20 MV/min) reduce processing time, providing a stark contrast to columns with 0.5 CV/min or slower flow rates.
Overview of Sartobind® Membranes
Sartobind® Rapid A Lab is a Protein A affinity chromatography unit offering a fast, flexible and future-proof solution for antibody purification. The pressure filter format can be effortlessly integrated into both benchtop and liquid chromatography system driven separation workflows, for scouting | preparative purification and proof of concept in research and development.
- Rapid capture on the fastest Protein A matrix
- Higher DBCs and lifetime yields than columns
- Flexible purification with or without equipment
Popular Applications:
- Monoclonal and polyclonal antibody capture
- Antibody drug conjugates and multi-specific antibodies
- Fc fusion protein and Fc receptor purification
Sartobind® Rapid A is a unique, scalable, and highly productive membrane platform for mAb capture. Sartobind® Rapid A has a scalable, single-use, and highly productive ‘plug & play’ membrane.
Sartobind® Q is highly flexible and is used in a wide range of applications, such as removal of HCP, DNA, viruses, and endotoxins. It is also used for virus and nucleic acid (DNA/RNA) purification. As with all Sartobind® membranes, the large pore structure is particularly suitable for large biomolecules.
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The new Sartobind® Q Mini has a membrane volume of 10|20 mL, allowing users easier scaling and perfectly suited for diagnostic product manufacturing. Sartobind® Mini is scalable with the existing Sartobind® portfolio, ranging from process development (Nano) to commercial production (Jumbo and cassettes).
Sartobind STIC® PA can operate at high conductivity and can remove DNA up to 1.5 M NaCl. DNA removal is possible even in the presence of phosphate buffers, offering unique processing capabilities.
The new Sartobind STIC® PA Mini has a membrane volume of 10 mL, allowing users easier scaling and perfectly suited for diagnostic product manufacturing. Sartobind® Mini is scalable with the existing Sartobind® portfolio, ranging from process development (Nano) to commercial production (Jumbo and cassettes).
Sartobind® S membrane adsorber is approved for use in drug production for the removal of host cell proteins at high flow rates. As a cation exchanger, Sartobind® S exhibits the ability to remove aggregates and typically achieves at least ten times higher binding capacity for viruses and virus-like particles (VLPs).
The new Sartobind® S Mini provides a membrane volume of 10|20 mL, allowing users easier scaling and perfectly suited for diagnostic product manufacturing. Sartobind® Mini is directly scalable with the existing Sartobind® portfolio, ranging from process development (Nano) to commercial production (Jumbo and cassettes).
Sartobind® Phenyl is a hydrophobic interaction membrane with low ligand substitution – enabling mild elution conditions for purifying all biomolecules.
Sartobind® Phenyl membranes can be considered a replacement for columns in polishing procedures (flow-through) and numerous binding and elution applications, as they operate at much higher flow rates, reduced complexity, and no size exclusion effects in purifying large biomolecules.
Typical dynamic binding capacity (DBC) at 10% breakthrough is:
• 9-13 mg/mL mAb
• 10 mg/mL BSA
• 23 mg/mL lysozyme
The new Sartobind® Phenyl Mini provides a membrane volume of 20 mL, allowing users easier scaling and perfectly suited for diagnostic product manufacturing. Sartobind® Mini is directly scalable with the existing Sartobind® portfolio, ranging from process development (Nano) to commercial production (Jumbo and cassettes).
