PPA HyperCel | Mixed-Mode Chromatography Resins

PPA HyperCel resin is a scalable chromatography resin designed for industrial use, capturing proteins and removing impurities in biopharmaceutical applications. Operating on a "mixed-mode" mechanism with a phenylpropylamine ligand, its behavior is based on a combination of electrostatic and hydrophobic interactions between proteins and ligands. PPA HyperCel resin offers unique selectivity, different from that provided by ion exchange or conventional hydrophobic interaction chromatography (HIC).

Features & Benefits:

• High mechanical and chemical stability
• Suitable for chromatography in biopharmaceutical environments
• Cross-linked cellulose base matrix

Applications:

• Protein purification at low ionic strength via direct hydrophobic capture
• Separation of challenging mixtures, e.g., protein isoforms or proteins with very close pI values
• Orthogonal separation mechanism to ion exchange or HIC