MEP HyperCel | Mixed-Mode Chromatography Resins

MEP HyperCel is a flexible mixed-mode chromatography resin designed for capturing and purifying antibodies and various recombinant proteins, from laboratory to production scale.

MEP HyperCel resin offers a salt-free/low-salt alternative to conventional HIC, simplifying processes and improving cost-efficiency by eliminating the need for salt addition and UF/DF steps. The MEP ligand is immunoglobulin-selective, making MEP HyperCel highly effective for capturing IgG and enhancing the removal of DNA, HCP, and aggregates. Elution occurs under mild conditions.

Features & Benefits:

• Unique separation mechanism and differentiated selectivity
• Direct protein capture from various raw materials
• No salt addition required for binding – simpler process, lower costs, and reduced waste
• Stable for harsh cleaning with NaOH

Applications:

• Alternative to hydrophobic interaction chromatography (HIC) without or with low salt
• Monoclonal and polyclonal IgG capture and intermediate purification (aggregate, DNA, and HCP removal)
• Direct capture of recombinant proteins or enzymes from raw materials without the need for pH or conductivity adjustments