Lysine HyperD® resin is a high-speed, high-capacity affinity resin designed for the preparative purification of biological molecules that bind to lysine, such as plasminogen from human or animal plasma. The Lysine HyperD affinity resin features a high-capacity hydrogel polymerized within the large pores of a rigid bead. This design combines the desirable high-capacity properties of soft gel with the dimensional stability of a rigid bead. The dynamic binding capacity is nearly independent of linear velocity. As a result, high productivity is achieved. The resin packs quickly due to the high density of the beads.