Resolute® ManuPak

• High resolution flow path provides optimum efficiency, capacity, and peak symmetry
• Central nozzle valve provides all column functions required for packing, unpacking, and running the column within a closed system
• Scalable, reproducible packing methods reduce validation efforts as processes scale up
• Common design from 300 to 1000 mm diameter (and up to 2000 mm on request)
• Designed to minimize packing events and buffer usage to optimize process economics
• Options for manual or remote controlled nozzle valves

Designed for Durability, Reliability, Versatility and Ease of Use

Resolute® ManuPak are available in diameters from 300 mm to 1000 mm, with 100 mm bed height adjustment and choice of bed heights up to 400 mm. Alternative bed height adjustment and diameters up to 2000 mm are available on request. Resolute® ManuPak feature:

• Manually operated nozzle valves. (See column options for pneumatically-actuated nozzle valves)
• Choice of bed supports in polyethylene or 316L stainless steel
• Acrylic column tube provides visibility of the packed bed
• Simple, constant compression, adjuster seal, and precision bore eliminate need for additional mechanical or pneumatic activation of adjuster seals
• Stainless steel support frame equipped with lockable castors (available up to 1000 mm column)

Optimized for Efficiency and Scale Up

Resolute® ManuPak columns are equipped with high resolution mobile phase flow path which consists of a mobile phase flow path within the nozzle valve body, distribution end cells, and a fully flushed piston seal arrangement. The performance of these important column components is essential for optimal process efficiency, capacity, and peak symmetry.

Resolute® ManuPak columns maintain identical design parameters throughout both the standard column range (from 300 mm to 1000 mm diameter) and the larger capacity columns (up to 2000 mm diameter). Operation at high linear velocities is free from non-linear column effects and assures true linear scalability of column performance, enabling users to scale up simply without method redevelopment or impact on the reproducibility of the packing process.

Key flow path features:

• Nozzle valve mobile phase path delivers consistent low pressure drop across column for true linear scale up
• Distribution with coned end cell channels provides near plug flow conditions
• Secondary cone on support ribs provides unimpeded route via top central nozzle for simple and effective removal of entrapped air as well as effective recovery of slurry via bottom central nozzle when unpacking
• Nozzle tip retracts flush with bed support with no protrusion into packed bed