CIMmultus® is a unique and industrially proven line of pre-packaged chromatography monolithic columns with high flow channels, designed to work with large biomolecules such as viruses (AAV, adenovirus, lentivirus, influenza, bacteriophages), nucleic acids (mRNA, pDNA), viral and exosomes. CIMmultus® columns can be used as disposable or single-use columns.

CIMmultus® monoliths are high-resolution chromatography devices designed for multiple scalable purification of complex biological samples. Inside the specially designed housing is a one-piece stationary phase with a homogeneous channel size and surface chemistry. This stationary phase is designed to simplify the transfer of methods from development to production.

Product features:

  • weak anion exchanger
  • working range, pH 2–9
  • binds molecules with predominantly negative charge, repels molecules with predominantly positive charge
  • capture, intermediate, or polishing steps in either bind-elute or flow-through mode
  • high capacity for plasmid DNA
  • sanitizable with 1 M NaOH

Application Note: Increasing Productivity of pDNA DSP Using Sample Displacement Chromatography
Application Note: Purification of mRNA by Affinity Chromatography on CIMmultus® Oligo dT Column
Application Note: Recovery of pDIKE2 Plasmid for Hepatitis C Vaccine Using CIMmultus® C4 HLD Monolith
Application Note: Chromatographic Separation of Full and Empty AAV8 Capsids
Datasheet: CIMmultus® Monolithic Columns - Pre-Packed Preparative Columns for Purification of Large Biomolecules
Poster: Preparation of Linear Plasmid DNA for in Vitro Transcription Reaction
Poster: Extraction of mRNA From IVT Mixtures With CIMmultus® Oligo dT Column

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