CIMmultus® is a unique and industrially proven line of pre-packaged chromatography monolithic columns with high flow channels, designed to work with large biomolecules such as viruses (AAV, adenovirus, lentivirus, influenza, bacteriophages), nucleic acids (mRNA, pDNA), viral and exosomes. CIMmultus® columns can be used as disposable or single-use columns.

CIMmultus® monoliths are high-resolution chromatography devices designed for multiple scalable purification of complex biological samples. Inside the specially designed housing is a one-piece stationary phase with a homogeneous channel size and surface chemistry. This stationary phase is designed to simplify the transfer of methods from development to production.

Product features:

  • multimodal chromatography ligand that combines elements of hydrogen bonding with anion exchange chromatography
  • unique selectivities in many important product areas
  • supports purification of single-stranded RNA at ambient temperature
  • fractionates ssRNA by size

Application Note: Increasing Productivity of pDNA DSP Using Sample Displacement Chromatography
Application Note: Purification of mRNA by Affinity Chromatography on CIMmultus® Oligo dT Column
Application Note: Recovery of pDIKE2 Plasmid for Hepatitis C Vaccine Using CIMmultus® C4 HLD Monolith
Application Note: Chromatographic Separation of Full and Empty AAV8 Capsids
Datasheet: CIMmultus® Monolithic Columns - Pre-Packed Preparative Columns for Purification of Large Biomolecules
Poster: Preparation of Linear Plasmid DNA for in Vitro Transcription Reaction
Poster: Extraction of mRNA From IVT Mixtures With CIMmultus® Oligo dT Column