Flexact® BP System for Buffer Preparation
The Flexact® BP is a standardized configurable solution dedicated to buffer preparation in biopharmaceutical processes. Addressing the entire development cycle and production capacity needs from 50 L to 3.000 L. The system provides recipe based control for all critical parameters. The automation allows operators to perform other tasks during the media preparation operation.
Price: On request
The unit operation is often placed in a separate buffer preparation room/area (clean room area 1). Challenges are the powder mixing time and particulate filtration filling into a receiving bag. The buffer can have a defined pH and conductivity value. The buffer is prepared with different components which could have a low solubility or a high viscosity. Buffer components could be added as a solid (powder addition via antistatic bags) or liquid (via 2D bags and titration line). The adjustment depends on the buffer strength, acid/base strengths, volume and titration line diameter. Therefore, scale down trials are recommended.
FLEXACT® BP SYSTEM AUTOMATION SEQUENCE:
- Pre-flush (optional)
- Prefill supply tank
- Buffer powder addition
- Homogenization (conductivity monitoring)
- Final fill and liquid adjustment
- Filter transfer to receiving tank(s)
