Celsius® Pak Bags - Sartorius Croatia

Celsius® Pak Bags

Celsius® CFT is an industry-leading platform technology that controls freezing and thawing rates to minimize cryo-concentration in biopharmaceutical products. This platform ensures substances are well-protected and offers flexibility by processing up to 100L in single-use Celsius® Paks.
Celsius® CFT platform
Price: On request

Celsius® CFT (Controlled Freeze & Thaw) is a platform technology for controlled-rate freezing and thawing of biopharmaceutical products. Celsius® CFT features Celsius® Paks which are sterile, pre-assembled and ready to use single-use bags designed to fit into reusable structural frames. Celsius® CFT minimizes cryo-concentration during freeze & thaw cycles. Celsius® CFT processes up to 100L of product per cycle in the Celsius® FT100 system and offers well-qualified shipping solutions for transferring frozen drug substances around the world.

Maximum product security

  • Extensive functional qualification in real process conditions
  • Optimized logistics from fill through drain
  • Minimize cryo-concentration and stabilize drug substances

Excellent process reliability

  • Total integration with monitoring of critical process parameters and process control
  • Pre-qualified shipper (ASTM D4169 AL1 mechanical ISTA7D extreme summer thermal performances)
  • Excellent reproducibility of the freeze and thaw cycles

Process Flexibility

  • Improves production management
  • Facilitates any process transfer
  • Reduces process time with fast freeze and thaw processes

Process scalability

  • In performances: Benchtop (30mL) to production (100L)
  • In capacity: Flexible production platform (up to 100L with Celsius® FT100)
  • In contact material: Same film for all Celsius® products for easy scale-up

Celsius® Paks are available in sizes of 1L, 2L, 8.3L and 16.6L nominal fill volumes and feature a variety of connections to allow fluid transfer across the entire drug manufacturing process.

Inlet and outlet connectors

  • Opta® SFT Male enables sterile connections to other single-use systems
  • CPC quick couplers are used for either sanitary connection or aseptic connection under ISO5 laminar air flow to single-use systems
  • Press in plug equipped with clear C-Flex® for sterile weld connection with BioWelder® TC and sterile seal disconnection with BioSealer®

Brochure: Celsius® CFT - The Controlled-Rate Freeze & Thaw Platform Technology
Brochure: Celsius® Product Lines - Discover our Freezing Capabilities
Flyer: Celsius® CFT - Protecting Your Drug Substances in Controlled-rate Freeze & Thaw Manufacturing
Publication: Large-Scale Freezing of Biologics - A Practitioner’s Review, Part 2: Practical Advice
Publication: Bulk Freeze-Thawing of Macromolecules published in BioProcess technical
Publication: Scale up case study for long term storage of a process intermediate in bags